Minature green monsters tear through the small town of Kingston Falls. Hijinks ensue as a mild-mannered bank teller releases these hideous loonies after gaining a new pet and violating two of three simple rules: No water (violated), no food after midnight (violated), and no bright light. Hilarious mayhem and destruction in a town straight out of Norman Rockwell. So, when your washing machine blows up or your TV goes on the fritz, before you call the repair man, turn on all the lights and look under all the beds. 'Cause you never can tell, there just might be a gremlin in your house.

A few years after the incident in Gremlins, Billy and Kate have moved to New York where they work for media mogul Daniel Clamp. Meanwhile, Gizmo's former owner has just died and he's been captured for the genetics part of the Clamp building. A little while later, a certain someone gets wet, creates a new Gremlin species, and learns to finally fight back after years of abuse. And while Gizmo and the surviving humans fight back, the Gremlins and their evil leader, the Brain Gremlin, are planning to escape when it gets dark. And if they do, New York will experience a new Hell.